Apparently, someone at Marvel is teasing a Mary Jane death. See more in a deliberate tease here:
http://www.silverbulletcomicbooks.com/rage/index1.htmI'm not really too floored, since with all the alternate reality, alternate timeline mini-series that writers like to toss out. It could be one of those. Like "Spider-Man: Death for the Redhead" or some shit-- a 6 issue, $5.95 series featuring Spidey written by some indy comic loon.
But..let's say it's legit. People would cry "you can't kill MJ!!" However, I don't think she's necessarily the Lois to Spidey's Superman.
The actual deed would, presumably, spin out of Peter's big ID reveal in "Civil War".